Fluorescent Discrimination between Traces of Chemical Warfare Agents and Their Mimics

Significance Statement

Prof. Tomás Torroba’s group at the University of Burgos in Spain has synthesized a new series of fluorogenic probes to obtain discrimination between traces of chemical warfare agents (CWA) and their mimics, in water or organic solvent. The new probes were tested against chemical warfare agents by Pär Wästerby´s group at the Swedish Defence Research Agency in Sweden, who also proved the discrimination power using Multivariate Data Analysis.  The synthesis of the reported fluorogenic probes is simple and straightforward, and should be relatively simple to adapt in technological applications for in field detection of CWA.

 

Fluorescent Discrimination between Traces of Chemical Warfare Agents and Their Mimics - advances in engineering. Advances In Engineering

 

 

 

 

 

 

J. Am. Chem. Soc., 2014, 136 (11), pp 4125–4128.

Borja Díaz de Greñu , Daniel Moreno ,Tomás Torroba *, Alexander Berg ,Johan Gunnars , Tobias Nilsson ,Rasmus Nyman , Milton Persson ,Johannes Pettersson , Ida Eklind §, andPär Wästerby *§

Department of Chemistry, Faculty of Sciences, University of Burgos, 09001 Burgos, Spain.
Department of Physics, Umeå University, SE-90187 Umeå, Sweden
§ Department for CBRN Defense and Security, Swedish Defense Research Agency (FOI), SE-90182 Umeå, Sweden.
ABSTRACT
An array of fluorogenic probes is able to discriminate between nerve agents, sarin, soman, tabun, VX and their mimics, in water or organic solvent, by qualitative fluorescence patterns and quantitative multivariate analysis, thus making the system suitable for the in-the-field detection of traces of chemical warfare agents as well as to differentiate between the real nerve agents and other related compounds.

Check Also

Miniaturized indirect ophthalmoscopy promises an affordable solution to foster smartphone wide-field fundus photography in telemedicine - Advances in Engineering

Miniaturized indirect ophthalmoscopy promises an affordable solution to foster smartphone wide-field fundus photography in telemedicine