Significant degradability enhancement in multilayer coating of polycaprolactone-bioactive glass/gelatin-bioactive glass on magnesium scaffold for tissue engineering applications

Applied Surface Science, Volume 338, 2015, Pages 137-145.

Mostafa Yazdimamaghani1,2, Mehdi Razavi2,  Daryoosh Vashaee3, Venkata Raveendra Pothineni4,Jayakumar Rajadas4,5,6, Lobat Tayebi2, 4, 7.

 

  1. School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA.
  2. School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA.
  3. Electrical and Computer Engineering Department, North Carolina State University, Raleigh, NC 27606, USA.
  4. Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Palo Alto, CA 94305, USA.
  5. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
  6. Stanford Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
  7. Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI 53233, USA.

 

Abstract

Magnesium (Mg) is a promising candidate to be used in medical products especially as bone tissue engineering scaffolds. The main challenge for using Mg in biomedical applications is its high degradation rate in the body. For this reason, in this study, a multilayer polymeric layer composed of polycaprolactone (PCL) and gelatin (Gel) reinforced with bioactive glass (BaG) particles has been applied on the surface of Mg scaffolds. The materials characteristics of uncoated Mg scaffold, Mg scaffold coated only with PCL-BaG and Mg scaffold coated with PCL-BaG and Gel-BaG have been analyzed and compared in detail. Scanning electron microscope (SEM) equipped with energy dispersive spectroscopy (EDS), and Fourier transform infrared spectroscopy (FTIR) were utilized for microstructural studies. In vitro bioactivity and biodegradation evaluations were carried out by submerging the scaffolds in simulated body fluid (SBF) at pre-determined time points. The results demonstrated that Mg scaffold coated with PCL-bioactive glass and Gel-bioactive glass exhibited significant improvement in biodegradability.

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tissue engineering applications