A Noble Biomaterial: TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing

Significance

There has been significant technology advances in fabrication of biomaterials for use in various medical prosthesis applications. Unfortunately, most of the available biomaterials are susceptible to numerous infections which render most of them unfit for medical use. This has resulted in unsafe repeated surgical operations and permanent malformations. This has attracted significant attention of many researchers with the aim of reducing infection resulting from the biomaterials.

Despite the use of strict aseptic surgical procedures and antibiotic prophylaxis, the infection rate has still been on the rise. To this end, researchers have been looking for an alternative method for developing biomaterials with surface antibacterial functions to prevent bacterial infections. Among the available materials for the joint prosthesis and fracture fixation, silver nanoparticles are the commonly used antibacterial agent owing to its excellent properties including low resistance and longer lifespan. However, the addition of silver to titanium material has been identified as a good approach not only for improving the antibacterial property but also to reduce corrosion and release of ions in the surgical wounds.

To this note, several techniques such as plasma injection and ion-beam-assisted deposition have been developed for producing nano-silver coatings on the titanium surface. However, the methods are associated with some limitations like poor bonding of the coating to the substrate and uncontrolled release of silver ions which may result in further infections and medical complications. Friction stir processing technique for processing matrix nanocomposites has been recently identified with the potential of overcoming the aforementioned limitations. Even though it has been widely used in other applications like aerospace, its applicability in the medical field has not been fully explored. Consequently, the effects of surfaces modified by friction stir processing method on adhesion and increase of bacteria have not been investigated.

Recently, a group of researchers at Shanghai Jiao Tong University led by Professor Liqiang Wang and Professor Yuanfei Fu utilized friction stir processing method to deposit silver nanoparticles on titanium substrate. They further investigated the effects of friction stir processing and the addition of silver nanoparticles to titanium surface on the microstructure, corrosion, and antibacterial properties. They managed to improve the antibacterial property of the nanocomposite. The work is published in the journal, ACS Applied Materials and Interfaces.

The authors observed that the silver nanoparticles were homogenously distributed on the titanium surface. Both friction stir processing and the addition of silver increased the corrosion resistance of the modified samples. For instance, the sample reduced the bacterial strain and adhesion with no any resulting cytotoxicity to the bone stem cells. Furthermore, the release of silver ions had negligible effects on the antibacterial effect as compared to the number of deposited silver nanoparticles on the surface.

The study by Zhi Yang and colleagues will therefore advance fabrication of biomaterials with high-level biocompatibility and improved antibacterial properties for medical applications. The approach is promising for efficient controlling the cytotoxicity of the infection-related biomaterials due to its excellent properties like good corrosion resistance, cytocompatibility and desired antibacterial capability.

A Noble Biomaterial: TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing - Advances in Engineering

A Noble Biomaterial: TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing - Advances in Engineering

About the author

Yuanfei Fu, Deputy Chief Physician, Deputy Director of Chinese Dental Technologist Association, has been working in the Department of Prosthodontics, the Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine for more than 15 years. He got Master’s degree in Shanghai Second Medical University in 2000 and received PhD degree in Shanghai Jiao Tong University School of Medicine in 2006.

He is doing research on implant materials, dental prosthetic material and oral tissue regeneration.

About the author

Liqiang Wang is an Associate Professor in the department of Materials Science and Engineering at Shanghai Jiao Tong University. He got his BS and MS degrees both in Xi’an University of Architecture and Technology in Materials Science in 2006. During 2004 to 2005, he joined as a researcher in Northwest Institute for Nonferrous Metal Research focus on beta titanium alloys. After receiving his PhD in Materials Science and Engineering at Shanghai Jiao Tong University in 2009, Dr Wang held position as Assiatant Professor at Shanghai Jiao Tong University and Visiting Professor at Northwestern University.

He focuses the research on the preparing, processing and analysing of biomedical titanium alloys and titanium matrix composites.

Reference

Yang, Z., Gu, H., Sha, G., Lu, W., Yu, W., & Zhang, W., Fu, Y., Wang, K., & Wang, L. (2018). TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing: Surface Characterization, Antibacterial Property, and Cytotoxicity in VitroACS Applied Materials & Interfaces, 10(48), 41155-41166.

Go To ACS Applied Materials & Interfaces

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