Development of an off‐grid solar‐powered autonomous chemical mini‐plant for producing fine chemicals


Photochemistry using inexhaustible solar energy is an eco-friendly way to produce fine chemicals outside the typical laboratory or chemical plant environment. However, variations in solar irradiation conditions and the need for an external energy source to power electronic components limits the accessibility of this approach.

Professor Timothy Noël and co-workers in the Flow Chemistry group of the University of Amsterdam’s Van’t Hoff Institute for Molecular Sciences have developed a fully operational standalone solar-powered mini-reactor which offers the potential for the production of fine chemicals in remote locations on Earth, and possibly even on Mars. In a paper published by ChemSusChem, the team present their unique, fully off-grid photochemistry system.

The new system, which is capable of synthesizing drugs and other chemicals in economically relevant volumes, “shines in isolated environments and allows for the decentralization of the production of fine chemicals,” according to Professor Noël. “The mini-plant is based on the concept of photochemistry, using sunlight to directly ‘power’ the chemical synthesis. We employ a photocatalyst, a chemical species that drives the synthesis when illuminated,” Noël continues. “Normally powerful LEDs or other lighting equipment are used for the illumination, but we choose to use sunlight. For starters, this renders the synthesis fully sustainable. But it also enables stand-alone operation in remote locations. Our dream is to see our system used at a base on the Moon or on Mars, where self-sustaining systems are needed to provide energy, food and medicine. Our mini-plant could contribute to this in a fully autonomous, independent way.”

Development of the mini-plant started around five years ago when the Noël research group—at the time based at Eindhoven University of Technology—developed a “solar concentrator.” This is essentially a sheet of transparent plastic with micrometer-sized channels in which the chemical synthesis takes place. By adding dedicated dyes, the researchers developed the plastic into a solar guide and luminescent convertor. It captures sunlight and directs it towards the channels, while converting a substantial part of the light into red photons that drive the chemical conversion.

The research group had already demonstrated the solar flow reactor concept by synthesizing a range of medicinally relevant molecules, albeit on a laboratory scale in a controlled environment. Now, in their recent paper in ChemSusChem, they describe how they developed a viable, optimally effective autonomous photosynthesis system and employed it in field tests. They also provide an outlook on aspects such as application potential and economic performance.

The prototype solar flow reactor now covers an area of about 0.25 square meters. To make it fully autonomous, the researchers equipped it with a solar cell that provides the power for auxiliaries such as pumps and the control system. This solar cell is placed behind the flow reactor in a stacked configuration that ensures maximum efficiency per square centimeter, according to the authors. The more energetic wavelengths are used in the reactor to drive the photocatalyst. The remaining photons with wavelengths of 600-1100 nm are converted to electricity to drive the auxiliaries.

The researchers also compared the performance of the prototype system with production figures for the well-known photochemical synthesis of rose oxide. This product for the perfume industry is industrially produced by photochemical means because it is cleaner and more efficient than traditional chemical synthesis. The researchers calculated that a surprisingly small surface area would be required for their system to meet current annual demand—just 150 m2 would suffice. The system cost would be similar to current commercial photosynthesis systems. Only needed solar energy so there are no energy expenditures. This could be a sustainable strategy for future production of chemicals such as rose oxide or pharmaceuticals.

The authors demonstrate that there are opportunities for solar-driven chemical production in different places from hot to cold areas. ” What’s more, the system lends itself to application in unexpected locations. It is possible to even cover the facade of a building. Of course the output would then be smaller than when the system is placed at an optimal angle to the sun. But it certainly is possible—and how cool would it be to have the walls make chemicals!

Development of an off‐grid solar‐powered autonomous chemical mini‐plant for producing fine chemicals - Advances in Engineering

About the author

Timothy Noël, received in 2004 his MSc degree (Industrial Chemical Engineering) from the KaHo Sint-Lieven in Ghent. He then moved to Ghent University to obtain a PhD at the Laboratory for Organic and Bioorganic Synthesis under the supervision of Professor Johan Van der Eycken (2005-2009). Next, he crossed the ocean to work at Massachusetts Institute of Technology (MIT) as a Fulbright Postdoctoral Fellow with Professor Stephen L. Buchwald. At MIT, he worked on the development of new continuous-flow methods for cross-coupling chemistry at the MIT-Novartis Center for Continuous Manufacturing. He became assistant professor in 2012 and associate professor in 2017 at Eindhoven University of Technology. In 2020, he was promoted to Full Professor at the University of Amsterdam where he is the Chair of Flow Chemistry. His research interests are flow chemistry, homogeneous catalysis and organic synthesis.

He received in 2011 the Incentive Award for Young Researchers from the Comité de Gestion du Bulletin des Sociétés Chimiques Belges, in 2012 a VENI award from NWO and he was also finalist of the European Young Chemist Award 2012. In 2013, he received a Marie Curie Career Integration Grant from the European Union. He coordinated the Marie Skłodowska-Curie ETN program “Photo4Future” on the development of photoredox catalysis in photomicroreactors (2015-2018). In 2015, he obtained a prestigious VIDI award from NWO. And in 2016, he received the Thieme Chemistry Journal Award. His research on photochemistry in microfluidic reactors was awarded the DECHEMA award 2017 and the Hoogewerff Jongerenprijs 2019. After 4 years as an associate editor of Journal of Flow Chemistry, he took over as editor in chief in 2019.


Tom M. Masson, Stefan D. A. Zondag, Koen P. L. Kuijpers, Dario Cambié, Michael G. Debije, Timothy Noel. Development of an off‐grid solar‐powered autonomous chemical mini‐plant for producing fine chemicals. ChemSusChem, 2021; DOI: 10.1002/cssc.202102011

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