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Journal Reference
Angewandte Chemie International Edition, Volume 54, Issue 28, pages 8263–8266, 2015.
Yusuke Kuroda,Dr. Shingo Harada,Akinori Oonishi,Dr. Yousuke Yamaoka,Prof. Dr. Ken-ichi Yamada,Prof. Dr. Kiyosei Takasu
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501 (Japan)
Abstract
A Brønsted-acid-catalyzed intramolecular enantioselective SN2′ reaction was developed utilizing trichloroacetimidate as a leaving group. The findings indicated that dual activation of the substrates is operative. This metal-free allylic alkylation allows highly enantioselective access to 2-vinylpyrrolidines bearing various substituents.
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