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J Am Chem Soc. 2014 May 7;136(18):6594-7.
Zuhai Lei and Youjun Yang
State Key Laboratory of Bioreactor Engineering, ‡Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
Abstract
A turn-on signal from zero background allows sensitive detection of a weak signal and is highly desired. The “covalent-assembly” probe design principle is powerful in this regard. Herein, we report an embodiment of this principle (NA570) for detection of Sarin related threats, based on a phenylogous Vilsmeier-Haack reaction. NA570 bears a concise molecular construct, exhibits a colorimetric and a fluorimetric signal, and has potential for real applications.
Significance Statement:
There is an urgent need for better detection methods for chemical threats worldwide. This paper discusses a sensitive and fast method to detect a chemical welfare (Sarin).
