Journal of Electroanalytical Chemistry, Volume 739, 2015, Pages 66–72. Kaixin Zhang1,2 , Jingkun Xu2, , Xiaofei Zhu2, Limin Lu1, Xuemin Duan2 ,Dufen Hu2, Liqi Dong2, Hui Sun2, Yansha Gao2, Yao Wu2
- College of Science, Jiangxi Agricultural University, Nanchang 330045, PR China
- School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China
Hierarchical nanocomposites of poly(3,4-ethylenedioxythiophene) nanorods array on graphene oxide nanosheets (PEDOT/GO) were synthesized via a liquid–liquid interfacial polymerization method. The synthesized composites were characterized by using Fourier transform infrared (FTIR) and Raman spectroscopic studies, and their morphology was analyzed by transmission electron microscopy (TEM). Characterization and surface morphology results indicated that PEDOT with a nanorods-like structure successfully anchored on the surface of GO sheets, which could enhance the electro-active sites of the nanocomposites. Then the obtained PEDOT/GO nanocomposites were utilized to modify glassy carbon electrode and designed for the trace level sensing of rutin. Electrochemical results revealed that the PEDOT/GO nanocomposites modified electrode exhibited larger oxidation peak currents of rutin than pure PEDOT and GO owing to the synergistic effect of GO and PEDOT nanorods. Under optimized conditions, the anodic peak current was linear to the concentration of rutin in the range from 0.004 to 60 μM with the detection limit of 0.00125 μM. To further validate its possible application, the proposed method was successfully used for the determination of rutin in pharmaceutical formulations with satisfactory results.