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Xinglei Zhang, Yan Liu, Jinghua Zhang, Zhong Hu, Bin Hu, Liying Ding, Li Jia, Huanwen Chen
Talanta, Volume 85, Issue 3, September 2011
Abstract
High throughput analysis of sunscreen agents present in cream cosmetic has been demonstrated, typically 2 samples per minute, using neutral desorption extractive electrospray ionization mass spectrometry (ND-EESI-MS) without sample pretreatment. For the targeted compounds such as 4-Aminobenzoic acid and oxybenzone, ND-EESI-MS method provided linear signal responses in the range of 1–100 ppb. Limits of detection (LOD) of the method were estimated at sub-ppb levels for the analytes tested. Reasonable relative standard deviation (RSD = 8.4–16.0%) was obtained as a result of 10 independent measurements for commercial cosmetics samples spiked with each individual sunscreen agents at 1–10 ppb. Acceptable recoveries were achieved in the range of 87–116% for direct analysis of commercial cream cosmetic samples. The experimental data demonstrate that ND-EESI-MS is a useful tool for high throughput screening of sunscreen agents in highly viscous cream cosmetic products, with the capability to obtain quantitative information of the analytes.
Cosmetic products have become our daily necessities in modern society. Cosmetic products are types of heterogeneous
liquid samples of high viscosities. Fast detection of trace illicit additives such as sunscreen agents, hormones and antibiotics in cream cosmetic products is highly desirable, but many challenges have to be faced due to the complexity of the samples.
As demonstrated here, trace amounts of illicit additives present in the viscous cosmetics products were sensitively liberated using a sealable geometry-independent neutral desorption (GIND) device, and were thereby rapidly detected and identified by tandem EESI-MS, without any sample pretreatment. This ND-EESI-MS will be very useful for fast screening and identified illicit additives such as sunscreen agents, hormones and antibiotics in such highly complex viscous samples. The operating procedure for this technique can be seen from the reference [H.W. Chen et al., Nat. protoc., 2011, 6(7):1010-1025].
Go to Journal: H.W. Chen et al., Neutral desorption extractive electrospray ionization mass spectrometry for fast screening sunscreen agents in cream cosmetic products. Talanta, 2011, 85(3):1665-1671
H.W. Chen et al., Trace detection of hormones and sulfonamides in viscous cosmetic products by neutral desorption
extractive electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 2011, 46(8): 794-803
H.W. Chen, et al., Selective Detection of Diethylene Glycol in Toothpaste Products Using Neutral Desorption Reactive
Extractive Electrospray Ionization Tandem Mass Spectrometry. Anal. Chem., 2009, 81 (20):8632–8638
