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Angewandte Chemie International Edition, Volume 51, Issue 33, pages 8314–8317, August 13, 2012.
Kai-Jiong Xiao, Dr. Ai-E Wang, Prof. Dr. Pei-Qiang Huang
Department of Chemistry and Fujian Provincial Key Laboratory for Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005 (P.R. China)
Abstract
Versatile and mild: The first general method for the title transformation has been developed (see scheme; 2-F-Py=2-fluoropyridine; Tf=trifluorosulfonyl). The amines are synthesized in good yields and the ketimine intermediates can be isolated before the reduction. This method should find applications in the synthesis of nitrogen-containing bioactive molecules and medicinal agents.
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