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Applied Surface Science, Volume 293, 28 February 2014, Pages 37-45.
S. Erakovic, A. Jankovic, C. Ristoscu, L. Duta, N. Serban, A. Visan, I.N. Mihailescu, G.E. Stan, M. Socol, O. Iordache, I. Dumitrescu, C.R. Luculescu, Dj. Janaćković, V. Miškovic-Stanković
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia and
National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele-Ilfov, Romania and
National Institute for Textile and Leather, 16 Lucretiu Patrascanu, 030508 Bucharest, Romania.
Abstract
Hydroxyapatite (HA) is a widely used biomaterial for implant thin films, largely recognized for its excellent capability to chemically bond to hard tissue inducing the osteogenesis without immune response from human tissues. Nowadays, intense research efforts are focused on development of antimicrobial HA doped thin films. In particular, HA doped with Ag (Ag:HA) is expected to inhibit the attachment of microbes and contamination of metallic implant surface. We herewith report on nano-sized HA and Ag:HA thin films synthesized by pulsed laser deposition on pure Ti and Ti modified with 100 nm diameter TiO2 nanotubes (fabricated by anodization of Ti plates) substrates. The HA-based thin films were characterized by SEM, AFM, EDS, FTIR, and XRD. The cytotoxic activity was tested with HEp2 cells against controls. The antifungal efficiency of the deposited layers was tested against the Candida albicans and Aspergillus nigerstrains. The Ti substrates modified with TiO2 nanotubes covered with Ag:HA thin films showed the highest antifungal activity.
