Strophasterols A to D with an unprecedented steroid skeleton: from the mushroom Stropharia rugosoannulata.

Wu J, Tokuyama S, Nagai K, Yasuda N, Noguchi K, Matsumoto T, Hirai H, Kawagishi H.

Angew Chem Int Ed Engl. 2012 Oct 22;51(43):10820-2.

Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.

Abstract

 

Skeletons in the closet: Four new compounds have been isolated from the title mushroom. The compounds display a new steroid skeleton (e.g., 1) not previously reported for steroids. Preliminary bioactivity tests show that compound 1 can protect neuronal cells by attenuating the endoplasmic reticulum stress, and has weak anti-methicillin-resistant Staphylococcus aureus activity.

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Strophasterols A to D with an Unprecedented Steroid Skeleton From the Mushroom Stropharia rugosoannulata

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